Abstract: Based on the hypothesis of Resource Curse, this paper calculates the total factor productivity and resource utilization efficiency of 110 major cities in China from 2001 to 2010 by using the Slacks-based Measure DDF, and re-examines the hypothesis by using a panel data model. It is found that, in general, urban resource utilization efficiency has gradually increased year by year; in terms of resources variety, energy utilization efficiency is significantly higher than that of water and land resources, with the land resources utilization efficiency being the poorest; there is a significant negative correlation between the abundance in energy or resources and the urban economic growth, indicating that generalized Resource Curse does exist at the city level; resource utilization efficiency is an important conduction mechanism for the generation of curse effects.